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Multiple factors contribute to this effect

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Reversal of rotenone-induced dysfunction of astrocytic connexin43 by opening mitochondrial ATP-sensitive potassium channels

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Furthermore, oral probiotics can induce intestinal epithelial cells to produce macrophage chemotaxis protein 1 through Toll-like receptors (TLR), and then activate the mucosal immune system (Maldonado Galdeano et al., 2019

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All such effects are observations drawn from preclinical, in-vitro, and animal investigations

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