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However, ingestion of such high doses of glutathione is often accompanied by undesirable side effects such as nausea and/or other negative effects (e.g., taste aversion)

Therefore, iron metabolism, including iron uptake, transportation, utilization, may affect cell susceptibility to ferroptosis

The LEADER trial demonstrated cardiovascular benefit comparable to what semaglutide would later show in SUSTAIN-6, though with a somewhat smaller magnitude of effect

doi: 10.3389/fmolb.2023.1183808 98 DewidarBMeyerCDooleySMeindl-BeinkerAN

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