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Henderson, B

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The prevalence of children with DS worldwide is between 1:319 and 1:1000, and depends on the age of the mother (1/2000 in teenage girls to 1/40 in 42-year-old women) sociocultural, religious variables, and the possibility of terminating a pregnancy [2, 3, 4]

And it's very likely, I think, that micro-dosing will find its way in some of these areas like addiction or perhaps Alzheimer's disease, where you're really amplifying the anti-inflammatory aspects of the drug and not so much the appetite-reducing effects