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This gives it a significantly longer half-life, typically 2030 hours, compared to the native hormone's half-life of minutes

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This distinguishes retatrutide from GLP-1 receptor agonists such as semaglutide, which primarily target the GLP-1 receptor, and dual agonists such as tirzepatide, which act on GLP-1 and GIP receptors without activating the glucagon receptor.[3] This three-receptor profile is a major reason retatrutide has drawn interest in metabolic research

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1

These typically involve subcutaneous injection into the abdomen, thigh, or upper arm using a prefilled pen device