The mechanism of medicinal plants is broad, and includes regulation of intestinal microbiota composition and intestinal permeability, increased expression of both mRNA and claudin-1 protein, and anti-inflammatory effects (Chinese tea, hibiscus, liquorice, marshmallow, ginger root, peppermint, plantain, curcumin)
Although we did not directly measure serum or tissue levels of these agents in these mice, both interventions were associated with improvement in systemic AGE-related measures and metabolic indices, consistent with their intended modes of action, and their combination offered limited additional benefit beyond specific endpoints
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