These effects may be attributed to metformins immunomodulatory properties and its ability to modulate the gut microbiota
However, certain circumstances may warrant testing including pre-existing liver or kidney conditions where monitoring organ function during therapy provides appropriate oversight, specific health concerns that might benefit from objective biomarker assessment, desire to objectively measure oxidative stress markers or glutathione status before and during therapy, and medical conditions requiring monitoring for safety reasons
& Yang, K
A tale of plant glutathione S-transferases: Since 1970
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