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Abstract Background Cushings syndrome (CS) is characterized by profound metabolic derangements, including obesity, insulin resistance, diabetes mellitus, and dyslipidemia

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Eckburg et al., (24) used metagenomic analysis to discover the gut bacterial community is made up of six phyla: Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Fusobacteria , and Verrucomicrobia , with the majority of the organisms in a healthy bacterial community being anaerobic population, as shown in Figure 3 (52)