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During Phase I and Phase II liver detoxification, glutathione plays a pivotal role in transforming harmful substances into water-soluble compounds that can be easily excreted

However, there are some drugs which may help to control particular symptoms in withdrawal and which deserve consideration in certain situations though not recommended for routine use

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Cells were blocked with 5% BSA in PBS and incubated with primary antibodies overnight

Deletion of the key catalytic enzyme methylthioadenosine phosphorylase (MTAP) gene is associated with the sensitivity of GSK3368715, 331 and a current phase II clinical study of GSK3368715 in breast cancer has been enrolled (NCT04676516) (Table 1)