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In the only direct evaluation of brain insulin resistance in PD, insulin signaling abnormalities were identified in the dorsolateral prefrontal and posterior parietal cortex of those with cognitive impairment, but not in those who were cognitively normal [72]

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The full dose titration period takes 16 to 20 weeks for semaglutide and 20 weeks for tirzepatide, meaning maximum weight loss velocity typically begins 4 to 5 months after starting treatment