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Researchers value this combination for investigating complementary mechanisms within controlled laboratory environments

For positive mode a scan range from m/z 200-1000 was covered and in negative mode full scans were acquired from m/z 200 1000 (until min 20) and from m/z 600-1700 (min 20 to 40)

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Via direct targeting of TREM2 (triggering receptor expressed on myeloid cells 2), Hecubine alleviated neuroinflammation and oxidative stress in both in vivo (4 dpf zebrafish larvae) and in vitro (BV-2 microglial cells) models, by modulating the Nrf2 and TLR4 signaling pathways (Figure 3C) (Li et al., 2024)