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Bioavailability refers to the amount of a compound that enters circulation consumed and becomes active

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Much evidence suggests that activation of anorexogenic proopiomelanocortin (POMC) neurons and simultaneous inhibition of orexigenic neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons in the ARC appears to be one of the major mechanisms for GLP-1R mediated inhibition of food intake

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