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Even if the MTC is locally advanced or metastatic, total thyroidectomy with involved LN compartments dissection is recommended to preserve the function of speech, swallowing, and the parathyroid gland [1]

Pain relief, improved motion, and increased function are the main goals of surgery for most patients

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While moderate weight reduction may yield metabolic benefits, rapid or sustained weight loss is frequently associated with decreased bone mineral density, deterioration of bone microarchitecture, and heightened fracture risk

It was not until the 1960s that technological advances in particular, the radioimmunoassay for insulin developed by Yalow and Berson allowed scientists to clearly demonstrate the incretin effect in humans ( [26] )