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As a peptidomimetic rather than a true peptide, Dihexa resists gastrointestinal peptidase degradation and crosses the intestinal epithelium

Neuron 17 , 513522 (1996)

Several commenters requested that CMS not finalize these proposals due to resource constraints, particularly for small and rural hospitals, and a few commenters indicated the proposed effective date of January 1, 2026, would make complying with the requirements, if finalized as proposed, especially challenging