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Alcoholic Liver Disease (ALD) is the result of the way our body treats alcohol in the liver where alcohol metabolic products lead to the formation of Reactive Oxygen Species (ROS) that harm cells through interacting with fats, proteins, and DNA

But its GI side effect profile is also the most aggressive, with nausea rates reaching 40% to 50% and vomiting rates significantly higher than cagrilintide monotherapy

Conservative approaches extend this to 16-20 weeks for better GI tolerance

Generation of 5-phosphoribosyl-1-phosphate (PRPP) Ribose 5-phosphate is not used directly for either purine or pyrimidine synthesis, rather it is used to synthesize the "active pentose" 5-phosphoribosyl-1-pyrophosphate (PRPP)

doi: 10.1136/gutjnl-2021326305 108 XuSLiXZhangSQiCZhangZMaRet al