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Table of Contents How Retatrutide Works and Its Effect on Body Weight Common Reasons Weight May Increase During Treatment Factors That Can Slow or Reverse Weight Loss Progress When to Speak to Your Doctor or Prescriber Lifestyle Factors That Support Retatrutide's Effectiveness What the Current Evidence Says About Long-Term Outcomes Scientific References Frequently Asked Questions How Retatrutide Works and Its Effect on Body Weight Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, glucagon) that suppresses appetite and may increase energy expenditure, but it is not yet MHRA- or EMA-licensed and individual weight loss responses vary considerably