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It also works as a substrate for sirtuins - a family of seven proteins (SIRT1-SIRT7) found in different parts of cells

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In their separate Phase 2 trials, retatrutide monotherapy showed larger weight loss (~24.2% at 48 weeks, 12 mg) than standalone cagrilintide (~10.8% at 26 weeks, 4.5 mg), and indirect network meta-analyses rank retatrutide highly