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If a person with a sulfa allergy comes into contact with drugs containing the compound, they may experience a rash or hives, itchy skin or eyes, and swelling

Altering substituents on the aromatic rings can significantly change binding affinity to NNMT

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g ., in hepatocytes or in Kupffer cells), with a small portion stored in the spleen (in macrophages), the intestines (via short-term storage in intestinal cells), and in the bone marrow