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Tirzepatide, a dual GLP-1 and GIP receptor agonist, demonstrated even greater reductions in the SURMOUNT trials, with participants losing up to 22% of their starting weight

Network meta-analyses suggest that higher-dose semaglutide (1 mg and 2 mg weekly) and tirzepatide (a dual GIP/GLP-1 receptor agonist) demonstrate superior A1c reductions compared to other agents in the class, with mean reductions of 1.52.0% or greater from baseline

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