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Semaglutide ameliorates diabetic neuropathic pain by inhibiting neuroinflammation in the spinal cord

Finally, following recent concerns by regulatory agencies regarding a potential increase in suicidal behavior associated with GLP-1RAs 206 , we found 1 recent pharmacovigilance report showing 0.6% suicidal events among 41,236 safety reports for these medications 207 and an emulated target trial of 86,418 older adults with T2DM that did not identify any difference in suicidal ideation or behavior between GLP-1RAs and other antidiabetic medications over 1.5 years 208

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Caution is warranted in patients with pancreatitis history, diabetic retinopathy, uncontrolled hypertension, or severe kidney or liver disease

These check-ins are essential for managing muscle loss, addressing side effects, and making necessary adjustments to treatment plans