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In fact, acetaminophen-related liver damage is currently the most common cause of liver transplant in the US, with more than 56,000 emergency room visits per year from acetaminophen-related liver problems

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Mobasher MA, Gonzalez-Rodriguez A, Santamaria B, Ramos S, Martin MA, Goya L, Rada P, Letzig L, James LP, Cuadrado A, Martin-Perez J, Simpson KJ, Muntane J, Valverde AM.Protein tyrosine phosphatase 1B modulates GSK3beta/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity