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157 Another clinical trial in 53 patients with NASH found adding 1,200 mg of NAC per day to treatment with metformin for 48 weeks resulted in decreased ALT levels, liver fat, hepatocyte ballooning, and scores used to assess NAFLD activity compared with ursodeoxycholic acid or ursodeoxycholic acid plus NAC

Safety Profile Based on Available Data: Preclinical safety studies have not identified significant adverse effects from BPC-157 administration in animal models at doses substantially higher than those used in supplementation

While the activity of all HATs is dependent on acetyl-CoA availability, class III histone deacetylases (HDACs), known as sirtuins, additionally require NAD + as a cofactor