However, in an in vitro simulation of GI digestion, inulinase has been shown to effectively break down high-fructan ingredients, including inulin and garlic, as well as a high-fructan test meal containing garlic, onion, Brussels sprouts, and black beans.28 In addition, preliminary in-house randomized, blinded, placebo-controlled trials conducted by Kiwi Biosciences demonstrated significantly reduced flatulence and diarrhea events in healthy individuals who were given supplemental fructan hydrolase powder with a highly concentrated source of fructan in chicory root bars.26 More research is needed to determine whether inulinase and fructan hydrolase are effective tools for symptom management in IBS
These effects appear to be mediated, at least in part, through the GLP-1/Sirtuin (SIRT1) pathway or via suppression of myostatin, while concomitantly reducing inflammation, thereby mitigating muscle wasting associated with SO [92,93,94]
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