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This is because hypokalemia and thrombocytosis could occur due to the increase in erythrocyte metabolism following vitamin B12 therapy

Persistent side effects beyond 2 weeks after a dose increase Transient nausea, mild constipation, and decreased appetite are expected and normal during the 1 to 2 weeks after each dose increase

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For intranasal administration, commonly reported empirical dosing includes 100-200 mcg per nostril taken once or twice daily (obviously, BPC-157 should first be reconstituted in bacteriostatic water at an appropriate concentration for nasal delivery)