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When we evaluate lab results, we often use a tighter, more optimal range (also called the functional range) rather than the wide standard lab range provided by the lab

These include low blood sugar (hypoglycemia), pancreatitis, and worsening of diabetic retinopathy

Clinically this is how athletes present when they have "REDs", or relative energy deficiency in sport

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A 2025 narrative review in PMC specifically listed creatine monohydrate as a recommended supplement for individuals on GLP-1 receptor agonist therapy, noting its role in supporting strength and lean mass during pharmacotherapy-induced weight loss