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Although randomized studies have not shown an overall effect on the frequency of exacerbations, a post-hoc analysis of a clinical trial reported a decrease in their severity (87) Overall, these results demonstrate that A1PI augmentation therapy offers significant benefits in slowing the progression of emphysema and improving clinical outcomes for patients with AATD, underscoring the importance of timely and continuous treatment

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It suppresses macrophage activation and infiltration, reducing inflammatory mediator release and improving the liver's immune microenvironment

Free Radic Biol Med 21 : 157161

How Depression Affects Different Groups Depression presents differently in women, men, teens, and older adults