Aardvark Therapeutics ARD-101 Aardvarks lead candidate, oral ARD-101 , is a potent pan-agonist of bitter taste receptors (TAS2R) that stimulates enteroendocrine cells in the digestive tract, triggering the release of gut-peptide hormones like GLP-1 and cholecystokinin (CCK), a satiety hormone that activates gut-brain signaling to regulate hunger
On the other hand, dose-response relationships for these peptides are often biphasic or bell-shaped, meaning that more is not better and that higher concentrations can lose the effect or even reverse it
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Exploratory Phase 2A, double-blind, placebo-controlled, dose escalation study to determine the safety, tolerability, PD, and PK of HU6 for the Treatment of subjects with obese heart failure with preserved ejection fraction (HFpEF) [Internet]
A reduction in the expression of PINK1 was demonstrated to result in a significant decline in the function of the mitochondrial electron transport chain (ETC) as well as the mtDNA copy number in hepatocellular carcinoma cell lines, as evidenced in a study (Kung-Chun et al., 2019)
