Major causes include endocrinopathies, heat stress, chronic diseases like diabetes and hypertension, genetic and immunological disorders, testicular pathologies, obstructive reproductive tract disorders and genitourinary tract infections, environmental factors such as alcohol consumption, cigarette smoking, exposure to heavy metals and environmental pollutants, drug abuse, ageing, and iatrogenic and idiopathic causes
However, results vary based on the individual's baseline nutrient levels and physical health
2025;:CPB-EPUB-151051
When treating with supplements, repeat blood testing of vitamin B12 and folate levels is done to monitor and confirm adequate treatment
Vitamin K, on the other hand, has indicated the ability to relieve oxidant stress and to enhance the patients glycemic control that is affected by PCOS, in spite of the necessity for the in-depth studies necessary for the validation of these findings [133]