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This fall in IGF-1 generation induced by GH-resistance promotes lipid catabolism, oxidation of fatty acids and ketogenesis, an adaptive response to energy deprivation that deprioritizes linear growth to promote euglycemia and ensure survival [44]
Chaisawangwong W, Wang H, Kouo T, Salathe SF, Isser A, Bieler JG, et al Cross-reactivity of SARS-CoV-2 and influenza Aspecific T cells in individuals exposed to SARS-CoV-2
Younger adults sometimes experience faster weight loss initially but may plateau sooner, while those in their 30s and 40s often show sustained, gradual reductions over 12 months or longer
In other medications, this is a desirable effect to assist in disease management such as sodiumglucose transport protein 2 (SGLT-2) inhibitors and glucagon-like peptide-1 receptor (GLP-1) agonists when used to treat type 2 diabetes mellitus and topiramate when used for migraine prophylaxis and for patients with binge-eating disorder
