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A study has found that B-cell lymphoma 2 (BCL2) is almost universally upregulated in ADT treatment castration-sensitive PCa cells, and BCL2 in turn mediates bidirectional signaling between AR-BCL2 and PI3K pathway through non-classical functions, driving the transformation of hormone sensitive to castration resistant phenotype (38)

If this happens once per year, that is the cost of a nice dinner out

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That inverts the usual priority: gentle handling matters more than light protection