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Accordingly, other routes such as sc or oral administration are recommended over ip injection.[4] IP injections should not be conducted in the same animal more than once daily as cumulative substance absorption following repeated dosing may prove fatal.[1, 4] Injected substances should be sterile, isotonic, and non-irritating.[7] Intraperitoneal Injection Technique in mice The animal should be restrained with its head and body tilted downwards to ensure the organs are out of the way when performing the injection.[1, 7, 8] An appropriately sized needle (Table 1) should be injected from the caudal direction, at a slight angle to the abdominal wall, with a quick and firm movement, but only so far that the tip barely pierces the abdominal wall

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Improving protocols for PRP preparation and administration in patellar tendinopathy A major challenge in studying the efficacy of PRP in patellar tendinopathy is the lack of standardized protocols for preparing and administering PRP and the absence of protocol regarding uniformity on the correct amount and number of dosages

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