Proteome-wide covalent targeting of acidic residues with tunable N -aryl aziridines
Detection of protein carbonylation Levels of carbonylated proteins were determined with the OxyBlot protein oxidation detection kit following the manufacturers protocol (Millipore, Billerica, MA, USA)
An ideal acid cleavable linker antibody should remain intact during circulation to prevent premature payload release in normal tissues, reducing systemic toxicity
Electronic Code of Federal Regulations: 21 CFR 216.23 Current formal 503A Bulks List and the regulatory warning that list inclusion is not FDA approval or endorsement
Gundle KR, Kafchinski L, Gupta S, Griffin AM, Dickson BC, Chung PW, et al