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irritans life-cycle comprises theronts, trophonts, protomonts, and tomonts [2, 3]

The mechanism involves upregulation of VEGF expression a key growth factor in new blood vessel formation and activation of ERK1/2 signaling pathways that drive cell proliferation, migration, and angiogenesis

Experimental models have shown that oral butyrate ameliorates inflammation in ulcerative colitis (Vieira 2011)

Zhang W, Taylor SP, Ennis HA, Forlenza KN, Duran I, Li B, Sanchez JAO, Nevarez L, Nickerson DA, Bamshad M, University of Washington Center for Mendelian Genomics., Lachman RS, Krakow D, Cohn DH, "Expanding the genetic architecture and phenotypic spectrum in the skeletal ciliopathies", Human mutation 39 (1): 152-166 (2018)