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What the Thyroid Boxed Warning Actually Means Both semaglutide and tirzepatide carry an FDA boxed warning for thyroid C-cell tumours

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Oral GLP-1 weight loss medication Orfoglipron (Eli Lilly) is nearing an FDA decision with available expect mid-2026 Clinical trials show meaningful results: 12-16% 1,2 average weight loss, which is slightly less than injectables Side effects are similar: mostly gastrointestinal, such as nausea or diarrhea, typically improving over 23 months

10.1161/ATVBAHA.113.301586 44