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10.1016/j.cmet.2013.01.003 86 SegalL

For instance, the FXR agonist obeticholic acid (OCA) has been demonstrated to attenuate systemic inflammation by inhibiting the NF-B signaling pathway, while TGR5 activation similarly suppresses macrophage inflammatory responses 164,165,166

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As previously noted, there is a remarkable overlap between the typical pro-inflammatory cytokines and chemokines secreted by senescent cells (IL-1, IL-6, IL-8, TNF-, CCL2, CCL5, etc.)